Aquired a straight '68 F250 2WD body. Thinking of swapping the cab onto my '71 F250 Highboy. Sure this has probably been covered before, but what specific challenges am I looking at?

 

Although I haven’t done a swap, I recently had the cab off my 67. I believe it would be a easy swap, maybe a few different wires. The cab mount fasteners can be tricky, the bolt coming from the top threads into a special washer on the bottom side, then a nut under that. I think there must be a tool made to hold that washer while you remove the bolt. Not easy by yourself.
I would remove the hood, then take the front clip as one piece, inner, outer fenders and core support all together. Will make realignment much easier, plus better access to front cab mounts, steering and wires.
Should be an easy swap, hope this helps.